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Associations of ambient fine particulate matter and its constituents with serum complement C3 in a panel study of older adults in China
Pei, Lu1,2; Zhao, Meiduo1,2; Xu, Jing1,2; Li, Ang1,2; Luo, Kai1,2; Li, Runkui3,4; Yang, Mingan5; Xu, Qun1,2
2019-09-01
Source PublicationENVIRONMENTAL POLLUTION
ISSN0269-7491
Volume252Pages:1019-1025
Corresponding AuthorXu, Qun(xuqun@ibms.cams.cn)
AbstractEpidemiological studies have demonstrated association between the total mass of fine particulate matter (PM2.5) exposures and inflammation. There are few studies exploring the associations between PM2.5 constituents and the biomarkers of inflammation in older adults and the underlying biological mechanisms are not exact. In this study, we examined the associations between PM2.5 and its constituents (organic carbon (OC), elemental carbon (EC), total carbon (TC), polycyclic aromatic hydrocarbons (PAH5) and complement three factor (C3), an important biomarker of inflammation in a repeated panel of 175 older adults in Beijing, China. We have constructed three different linear mixed effect models (single-pollutant model, constituent-PM2.5 joint model, and constituent-residual model) to evaluate the association of PM2.5 and its constituents and complement C3, controlling for concentration of high sensitive C-reactive protein (hs-CRP), day of week, mean temperature, relative humidity, location and potential individual confounders. We found robust positive associations of OC, EC, TC, PAHs and PM2.5 mass concentration with complement C3 at different lag patterns. The cumulative effects of pollutants increased across average of 2-5 days. Individuals aged 65 and above, or with diabetes, or BMI >= 30, or with no-cardiopathy, or with hypertension also exhibited positive associations between PM2.5 and complement C3. The results revealed that short-term exposure to PM2.5 and its constituents could result in a significant increase in serum level of complement C3. These findings suggested a possible involvement of complement C3 in the effect of PM2.5 on inflammatory reaction. (C) 2019 Published by Elsevier Ltd.
KeywordPM2.5 constituents Health effect Complement C3 Short-term exposure
DOI10.1016/j.envpol.2019.05.096
WOS KeywordAIR-POLLUTION ; INSULIN-RESISTANCE ; INFLAMMATORY DISEASES ; HOSPITAL ADMISSIONS ; METABOLIC SYNDROME ; BLOOD-PRESSURE ; EXPOSURE ; MARKERS ; ACTIVATION ; SYSTEM
Indexed BySCI
Language英语
Funding ProjectChina Medical Board[15-230] ; National Key Research and Development Program of China[2017YFB0503605] ; Chinese Academy of Medical Science Innovation Fund for Medical Sciences[2017-I2M-1-009] ; Program of Science and Technology Service Network Initiative (STS) of Chinese Academy of Sciences[Y88Q0300YD] ; National Natural Science Foundation of China[41771435] ; China Scholarship Council[201704910297]
Funding OrganizationChina Medical Board ; National Key Research and Development Program of China ; Chinese Academy of Medical Science Innovation Fund for Medical Sciences ; Program of Science and Technology Service Network Initiative (STS) of Chinese Academy of Sciences ; National Natural Science Foundation of China ; China Scholarship Council
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS IDWOS:000483405400010
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.igsnrr.ac.cn/handle/311030/69750
Collection中国科学院地理科学与资源研究所
Corresponding AuthorXu, Qun
Affiliation1.Chinese Acad Med Sci, Sch Basic Med, Dept Epidemiol & Biostat, Inst Basic Med Sci,Peking Union Med Coll, Beijing 100005, Peoples R China
2.Chinese Acad Med Sci, Peking Union Med Coll, Ctr Environm & Hlth Sci, Beijing 100005, Peoples R China
3.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, State Key Lab Resources & Environm Informat Syst, Beijing 100101, Peoples R China
5.San Diego State Univ, Grad Sch Publ Hlth, Div Biostat & Epidemiol, San Diego, CA 92182 USA
Recommended Citation
GB/T 7714
Pei, Lu,Zhao, Meiduo,Xu, Jing,et al. Associations of ambient fine particulate matter and its constituents with serum complement C3 in a panel study of older adults in China[J]. ENVIRONMENTAL POLLUTION,2019,252:1019-1025.
APA Pei, Lu.,Zhao, Meiduo.,Xu, Jing.,Li, Ang.,Luo, Kai.,...&Xu, Qun.(2019).Associations of ambient fine particulate matter and its constituents with serum complement C3 in a panel study of older adults in China.ENVIRONMENTAL POLLUTION,252,1019-1025.
MLA Pei, Lu,et al."Associations of ambient fine particulate matter and its constituents with serum complement C3 in a panel study of older adults in China".ENVIRONMENTAL POLLUTION 252(2019):1019-1025.
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