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More Poop, More Precision: Improving Epidemiologic Surveillance of Soil-Transmitted Helminths with Multiple Fecal Sampling using the Kato-Katz Technique
Liu, Chengfang1; Lu, Louise2,5; Zhang, Linxiu3; Bai, Yu4; Medina, Alexis5; Rozelle, Scott5; Smith, Darvin Scott6; Zhou, Changhai7; Zang, Wei7
2017
Source PublicationAMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
ISSN0002-9637
Volume97Issue:3Pages:870-875
Corresponding AuthorLiu, Chengfang(cfliu.ccap@pku.edu.cn)
AbstractSoil-transmitted helminths, or parasitic intestinal worms, are among the most prevalent and geographically widespread parasitic infections in the world. Accurate diagnosis and quantification of helminth infection are critical for informing and assessing deworming interventions. The Kato-Katz thick smear technique, the most widely used laboratory method to quantitatively assess infection prevalence and infection intensity of helminths, has often been compared with other methods. Only a few small-scale studies, however, have considered ways to improve its diagnostic sensitivity. This study, conducted among 4,985 school-age children in an area of rural China with moderate prevalence of helminth infection, examines the effect on diagnostic sensitivity of the Kato-Katz technique when two fecal samples collected over consecutive days are examined and compared with a single sample. A secondary aim was to consider cost-effectiveness by calculating an estimate of the marginal costs of obtaining an additional fecal sample. Our findings show that analysis of an additional fecal sample led to increases of 23%, 26%, and 100% for Ascaris lumbricoides, Trichuris trichiura, and hookworm prevalence, respectively. The cost of collecting a second fecal sample for our study population was approximately USD4.60 per fecal sample. Overall, the findings suggest that investing 31% more capital in fecal sample collection prevents an underestimation of prevalence by about 21%, and hence improves the diagnostic sensitivity of the Kato-Katz method. Especially in areas with light-intensity infections of soil-transmitted helminths and limited public health resources, more accurate epidemiological surveillance using multiple fecal samples will critically inform decisions regarding infection control and prevention.
DOI10.4269/ajtmh.16-0728
WOS KeywordREPUBLIC-OF-CHINA ; STRONGYLOIDES-STERCORALIS ; SCHISTOSOMA-JAPONICUM ; EGG COUNTS ; INFECTIONS ; DIAGNOSIS ; HOOKWORM ; ACCURACY ; FLOTAC
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[71473240] ; National Natural Science Foundation of China[71333012] ; International Initiative for Impact Evaluation (3IE)[PW2.04.02.02]
Funding OrganizationNational Natural Science Foundation of China ; International Initiative for Impact Evaluation (3IE)
WOS Research AreaPublic, Environmental & Occupational Health ; Tropical Medicine
WOS SubjectPublic, Environmental & Occupational Health ; Tropical Medicine
WOS IDWOS:000423202900046
PublisherAMER SOC TROP MED & HYGIENE
Citation statistics
Document Type期刊论文
Identifierhttp://ir.igsnrr.ac.cn/handle/311030/56971
Collection中国科学院地理科学与资源研究所
Corresponding AuthorLiu, Chengfang
Affiliation1.Peking Univ, Sch Adv Agr Sci, China Ctr Agr Policy, Beijing 100871, Peoples R China
2.Yale Univ, Sch Med, New Haven, CT USA
3.Chinese Acad Sci, Inst Geog Sci & Nat Resource Res, Ctr Chinese Agr Policy, Beijing, Peoples R China
4.Shaanxi Normal Univ, Ctr Expt Econ Educ, Xian, Shaanxi, Peoples R China
5.Freeman Spogli Inst Int Studies, Rural Educ Action Program, Stanford, CA USA
6.Stanford Univ, Sch Med, Stanford, CA 94305 USA
7.Chinese Ctr Dis Control & Prevent, Natl Inst Parasit Dis, Shanghai, Peoples R China
Recommended Citation
GB/T 7714
Liu, Chengfang,Lu, Louise,Zhang, Linxiu,et al. More Poop, More Precision: Improving Epidemiologic Surveillance of Soil-Transmitted Helminths with Multiple Fecal Sampling using the Kato-Katz Technique[J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE,2017,97(3):870-875.
APA Liu, Chengfang.,Lu, Louise.,Zhang, Linxiu.,Bai, Yu.,Medina, Alexis.,...&Zang, Wei.(2017).More Poop, More Precision: Improving Epidemiologic Surveillance of Soil-Transmitted Helminths with Multiple Fecal Sampling using the Kato-Katz Technique.AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE,97(3),870-875.
MLA Liu, Chengfang,et al."More Poop, More Precision: Improving Epidemiologic Surveillance of Soil-Transmitted Helminths with Multiple Fecal Sampling using the Kato-Katz Technique".AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 97.3(2017):870-875.
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