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Meteorological factors affect the epidemiology of hemorrhagic fever with renal syndrome via altering the breeding and hantavirus-carrying states of rodents and mites: a 9 years' longitudinal study
Jiang, Fachun1; Wang, Ling2; Wang, Shuo2; Zhu, Lin2; Dong, Liyan1; Zhang, Zhentang3; Hao, Bi1; Yang, Fan2; Liu, Wenbin2; Deng, Yang2; Zhang, Yun4; Ma, Yajun5; Pan, Bei1; Han, Yalin1; Ren, Hongyan6; Cao, Guangwen2
2017-11-29
Source PublicationEMERGING MICROBES & INFECTIONS
ISSN2222-1751
Volume6Pages:9
Corresponding AuthorCao, Guangwen(gcao@smmu.edu.cn)
AbstractThe incidence of hemorrhagic fever with renal syndrome (HFRS) in Qingdao, China was three times higher than that of the average national level. Here we characterized the epidemiology, ecological determinants and pathogen evolution of HFRS in Qingdao during 2007-2015. In this longitudinal study, a total of 1846 HFRS patients and 41 HFRS-related deaths were reported. HFRS in Qingdao peaked once a year in the fourth quarter. We built a time series generalized additive model, and found that meteorological factors in the previous quarter could accurately predict HFRS occurrence. To explore how meteorological factors influenced the epidemic of HFRS, we analyzed the relationship between meteorological factors and hantavirus-carrying states of the hosts (including rodents and shrews). Comprehensive analysis showed humidity was correlated to high host densities in the third quarter and high hantavirus-carrying rates of animal hosts in the third to fourth quarters, which might contribute to HFRS peak in the fourth quarter. We further compared the L segments of hantaviruses from HFRS patients, animal hosts and ectoparasites. Phylogenetic analysis showed that hantaviruses in gamasid and trombiculid mites were the same as those from the hosts. This indicated mites also contributed to the transmission of hantavirus. Furthermore, Hantaan virus from HFRS patients, hosts and mites in Qingdao formed a distinct phylogenetic cluster. A new clade of Seoul virus was also identified in the hosts. Overall, meteorological factors increase HFRS incidence possibly via facilitating hosts' reproduction and consequent mite-mediated hantavirus transmission. New hantavirus subtypes evolved in Qingdao represent new challenges of fighting against HFRS.
KeywordChina hantavirus hemorrhagic fever with renal syndrome rodent meteorological factors
DOI10.1038/emi.2017.92
WOS KeywordRATTUS-NORVEGICUS ; LABORATORY RATS ; HANTAAN VIRUS ; CHINA ; TRANSMISSION ; ASSOCIATION ; SURVEILLANCE ; INFECTIONS ; PREVALENCE ; EUROPE
Indexed BySCI
Language英语
Funding ProjectQingdao Science and Technology Plan[14-2-3-29nsh] ; Key Research Fund from Chinese Military System[AWS16J023] ; National Natural Science Foundation of China[81473036]
Funding OrganizationQingdao Science and Technology Plan ; Key Research Fund from Chinese Military System ; National Natural Science Foundation of China
WOS Research AreaImmunology ; Microbiology
WOS SubjectImmunology ; Microbiology
WOS IDWOS:000417293700004
PublisherNATURE PUBLISHING GROUP
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.igsnrr.ac.cn/handle/311030/56809
Collection中国科学院地理科学与资源研究所
Corresponding AuthorCao, Guangwen
Affiliation1.Municipal Ctr Dis Control & Prevent Qingdao, Dept Acute Infect Dis, Qingdao, Peoples R China
2.Second Mil Med Univ, Dept Epidemiol, Shanghai, Peoples R China
3.Ctr Dis Control & Prevent Huangdao Dist, Qingdao, Peoples R China
4.Huadong Res Inst Med & Biotech, Inst Epidemiol & Microbiol, Nanjing, Jiangsu, Peoples R China
5.Second Mil Med Univ, Dept Trop Infect Dis, Shanghai, Peoples R China
6.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Jiang, Fachun,Wang, Ling,Wang, Shuo,et al. Meteorological factors affect the epidemiology of hemorrhagic fever with renal syndrome via altering the breeding and hantavirus-carrying states of rodents and mites: a 9 years' longitudinal study[J]. EMERGING MICROBES & INFECTIONS,2017,6:9.
APA Jiang, Fachun.,Wang, Ling.,Wang, Shuo.,Zhu, Lin.,Dong, Liyan.,...&Cao, Guangwen.(2017).Meteorological factors affect the epidemiology of hemorrhagic fever with renal syndrome via altering the breeding and hantavirus-carrying states of rodents and mites: a 9 years' longitudinal study.EMERGING MICROBES & INFECTIONS,6,9.
MLA Jiang, Fachun,et al."Meteorological factors affect the epidemiology of hemorrhagic fever with renal syndrome via altering the breeding and hantavirus-carrying states of rodents and mites: a 9 years' longitudinal study".EMERGING MICROBES & INFECTIONS 6(2017):9.
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