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Genomic insights into the pathogenicity and environmental adaptability of Enterococcus hirae R17 isolated from pork offered for retail sale
Peng, Zixin1,2; Li, Menghan1; Wang, Wei1; Liu, Hongtao3; Fanning, Seamus1,4; Hu, Yujie1; Zhang, Jianzhong2; Li, Fengqin1
2017-12-01
Source PublicationMICROBIOLOGYOPEN
ISSN2045-8827
Volume6Issue:6Pages:15
Corresponding AuthorZhang, Jianzhong(zhangjianzhong@icdc.cn) ; Li, Fengqin(lifengqin@cfsa.net.cn)
AbstractGenetic information about Enterococcus hirae is limited, a feature that has compromised our understanding of these clinically challenging bacteria. In this study, comparative analysis was performed of E.hirae R17, a daptomycin-resistant strain isolated from pork purchased from a retail market in Beijing, China, and three other enterococcal genomes (Enterococcusfaecium DO, Enterococcusfaecalis V583, and E.hirae ATCC9790). Some 1,412 genes were identified that represented the core genome together with an additional 139 genes that were specific to E.hirae R17. The functions of these R17 strain-specific coding sequences relate to the COGs categories of carbohydrate transport and metabolism and transcription, a finding that suggests the carbohydrate utilization capacity of E.hirae R17 may be more extensive when compared with the other three bacterial species (spp.). Analysis of genomic islands and virulence genes highlighted the potential that horizontal gene transfer played as a contributor of variations in pathogenicity in this isolate. Drug-resistance gene prediction and antibiotic susceptibility testing indicated E.hirae R17 was resistant to several antimicrobial compounds, including bacitracin, ciprofloxacin, daptomycin, erythromycin, and tetracycline, thereby limiting chemotherapeutic treatment options. Further, tolerance to biocides and metals may confer a phenotype that facilitates the survival and adaptation of this isolate against food preservatives, disinfectants, and antibacterial coatings. The genomic plasticity, mediated by IS elements, transposases, and tandem repeats, identified in the E.hirae R17 genome may support adaptation to new environmental niches, such as those that are found in hospitalized patients. A predicted transmissible plasmid, pRZ1, was found to carry several antimicrobial determinants, along with some predicted pathogenic genes. These data supported the previously determined phenotype confirming that the foodborne E.hirae R17 is a multidrug-resistant pathogenic bacterium with evident genome plasticity and environmental adaptability.
Keyworddrug-resistance gene Enterococcus hirae genomic island genomic plasticity mobile genetic element virulence gene
DOI10.1002/mbo3.514
WOS KeywordRESISTANT STAPHYLOCOCCUS-AUREUS ; BACILLUS-ANTHRACIS CAPSULE ; URINARY-TRACT-INFECTION ; ANTIMICROBIAL RESISTANCE ; ANTIBIOTIC-RESISTANCE ; DAPTOMYCIN RESISTANCE ; SPECIES DEFINITION ; VIRULENCE FACTORS ; GENES DATABASE ; ANIMAL ORIGIN
Indexed BySCI
Language英语
Funding ProjectBeijing Talents Fund of the Beijing Municipal Organization Department[2014000021223ZK46] ; Beijing Nova Program Interdisciplinary Cooperation Project[Z161100004916029] ; China Postdoctoral Science Foundation[2016M590072] ; National Natural Science Foundation of China[31601574]
Funding OrganizationBeijing Talents Fund of the Beijing Municipal Organization Department ; Beijing Nova Program Interdisciplinary Cooperation Project ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China
WOS Research AreaMicrobiology
WOS SubjectMicrobiology
WOS IDWOS:000417893600003
PublisherWILEY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.igsnrr.ac.cn/handle/311030/56785
Collection中国科学院地理科学与资源研究所
Corresponding AuthorZhang, Jianzhong; Li, Fengqin
Affiliation1.China Natl Ctr Food Safety Risk Assessment, Key Lab Food Safety Risk Assessment, Minist Hlth, Beijing, Peoples R China
2.Chinese Ctr Dis & Prevent, State Key Lab Infect Dis Prevent & Control, Collaborat Innovat Ctr Diag & Treatment Infect Di, Natl Inst Communicable Dis Control & Prevent, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, Beijing, Peoples R China
4.Univ Coll Dublin, UCD Ctr Food Safety, Sch Publ Hlth Physiotherapy & Sports Sci, Dublin, Ireland
Recommended Citation
GB/T 7714
Peng, Zixin,Li, Menghan,Wang, Wei,et al. Genomic insights into the pathogenicity and environmental adaptability of Enterococcus hirae R17 isolated from pork offered for retail sale[J]. MICROBIOLOGYOPEN,2017,6(6):15.
APA Peng, Zixin.,Li, Menghan.,Wang, Wei.,Liu, Hongtao.,Fanning, Seamus.,...&Li, Fengqin.(2017).Genomic insights into the pathogenicity and environmental adaptability of Enterococcus hirae R17 isolated from pork offered for retail sale.MICROBIOLOGYOPEN,6(6),15.
MLA Peng, Zixin,et al."Genomic insights into the pathogenicity and environmental adaptability of Enterococcus hirae R17 isolated from pork offered for retail sale".MICROBIOLOGYOPEN 6.6(2017):15.
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