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Spatial pattern and variations in the prevalence of congenital heart disease in children aged 4-18 years in the Qinghai-Tibetan Plateau
Ma, Li-Guang1,4; Chen, Qiu-Hong2; Wang, Yuan-Yuan1; Wang, Jing5; Ren, Zhou-Peng3; Cao, Zong-Fu1; Cao, Yan-Rong4; Ma, Xu1,6; Wang, Bin-Bin1,6
2018-06-15
Source PublicationSCIENCE OF THE TOTAL ENVIRONMENT
ISSN0048-9697
Volume627Pages:158-165
Corresponding AuthorChen, Qiu-Hong(chqh666@aliyun.com) ; Ma, Xu(nicgr@263.net) ; Wang, Bin-Bin(wbbahu@163.com)
AbstractPurpose: This study aimed to investigate the spatial distribution pattern of the prevalence of congenital heart disease (CHD) in children in Qinghai-Tibetan Plateau (QTP), a high-altitude region in China. Methods: Epidemiological data from a survey on the prevalence of CHD in Qinghai Province including 288,066 children (4-18 years) were used in this study. The prevalence and distribution pattern of CHD was determined by sex, CHD subtype, and nationality and altitude. Spatial pattern analysis using Getis-Ord Gi* was used to identify the spatial distribution of CHD. Bayesian spatial binomial regression was performed to examine the relationship between the prevalence of CHD and environmental risk factors in the QTP. Results: The prevalence of CHD showed a significant spatial clustering pattern. The Tibetan autonomous prefecture of Yushu (average altitude > 4000 m) and the Mongolian autonomous county of Henan (average altitude > 3600 m) in Huangnan had the highest prevalence of CHD. Univariate analysis showed that with ascending altitude, the total prevalence of CHD, that in girls and boys with CHD, and that of the subtypes PDA and ASD increasing accordingly. Thus, environmental factors greatly contributed to the prevalence of CHD. Conclusions: The prevalence of CHD shows significant spatial clustering pattern in the QTP. The CHD subtype prevalence clustering pattern has statistical regularity which would provide convenient clues of environmental risk factors. Our results may provide support to make strategies of CHD prevention, to reduce the incidence of CHD in high altitude regions of China. (C) 2018 Published by Elsevier B.V.
KeywordCongenital heart disease Qinghai-Tibetan Plateau Spatial pattern and distribution Environmental risk factor
DOI10.1016/j.scitotenv.2018.01.194
WOS KeywordHIGH-ALTITUDE ADAPTATION ; RISK-FACTORS ; DEFECTS ; EPIDEMIOLOGY ; ANOMALIES ; CHINA ; ENVIRONMENT ; POLLUTION ; EXPOSURE ; PROVINCE
Indexed BySCI
Language英语
Funding ProjectNSFC[41401469] ; NSFC[81460282] ; NSFC[81260299] ; National Key Research and Development Program of China[2016YFC1000300] ; National Key Research and Development Program of China[2016YFC1000307] ; Qinghai Applied Basic Research Project[2017-ZJ-725] ; National Infrastructure of Chinese Genetic Resources[YCZYPT[2017]01-6]
Funding OrganizationNSFC ; National Key Research and Development Program of China ; Qinghai Applied Basic Research Project ; National Infrastructure of Chinese Genetic Resources
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS IDWOS:000431848500016
PublisherELSEVIER SCIENCE BV
Citation statistics
Document Type期刊论文
Identifierhttp://ir.igsnrr.ac.cn/handle/311030/54863
Collection中国科学院地理科学与资源研究所
Corresponding AuthorChen, Qiu-Hong; Ma, Xu; Wang, Bin-Bin
Affiliation1.Natl Res Inst Family Planning, Beijing 100081, Peoples R China
2.Qinghai Cardiovasc Dis Vocat Hosp, Cent Lab, Xining 810012, Qinghai, Peoples R China
3.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, State Key Lab Resources & Environm Informat Syst, Beijing 100101, Peoples R China
4.Beijing GIStone Informat Technol Co Ltd, Beijing 100101, Peoples R China
5.Capital Med Univ, Sch Med Basic, Dept Med Genet & Dev Biol, Beijing 100069, Peoples R China
6.Peking Union Med Coll, Beijing 100730, Peoples R China
Recommended Citation
GB/T 7714
Ma, Li-Guang,Chen, Qiu-Hong,Wang, Yuan-Yuan,et al. Spatial pattern and variations in the prevalence of congenital heart disease in children aged 4-18 years in the Qinghai-Tibetan Plateau[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2018,627:158-165.
APA Ma, Li-Guang.,Chen, Qiu-Hong.,Wang, Yuan-Yuan.,Wang, Jing.,Ren, Zhou-Peng.,...&Wang, Bin-Bin.(2018).Spatial pattern and variations in the prevalence of congenital heart disease in children aged 4-18 years in the Qinghai-Tibetan Plateau.SCIENCE OF THE TOTAL ENVIRONMENT,627,158-165.
MLA Ma, Li-Guang,et al."Spatial pattern and variations in the prevalence of congenital heart disease in children aged 4-18 years in the Qinghai-Tibetan Plateau".SCIENCE OF THE TOTAL ENVIRONMENT 627(2018):158-165.
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