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Effects of arsenic methylation and metabolism on the changes of arsenic-related skin lesions
Wei, Binggan1; Yu, Jiangping1; Kong, Chang1,2; Li, Hairong1,2; Yang, Linsheng1,2; Xia, Yajuan3; Wu, Kegong3
2018-08-01
Source PublicationENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
ISSN0944-1344
Volume25Issue:24Pages:24394-24402
Corresponding AuthorLi, Hairong(lihr@igsnrr.ac.cn) ; Yang, Linsheng(yangls@igsnrr.ac.cn)
AbstractLittle was known about the arsenic metabolism and arsenic methylation associated with the changes of skin lesions after reducing the arsenic in drinking water (WAs). Therefore, urinary concentrations and proportions of arsenic species were determined for recovery (RC), improvement (IC), persistent (PE), aggravation (AC), new incidence (NC), and no sign (HC) groups based on the changes of skin lesions between before (in 2004) and after (in 2017) WAs reduction. The results indicate that the urinary concentrations of inorganic arsenic (iAs), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), and total arsenic (TAs) were much higher for RC and IC groups than for the other groups in 2004, while these values varied slightly among the groups in 2017. The urinary %iAs of all the groups was significantly decreased after WAs reduction. In contrast, the urinary %DMA of RC, IC, AC, and NC groups was increased. From 2004 to 2017, the PE and HC groups had lower decrease rate of %iAs and %MMA, and increase rate of %DMA, primary methylation index (PMI), and secondary methylation index (SMI) after WAs reduction. The adjusted odd ratios (ORs) showed that the RC, IC, AC, and NC groups were positively related with %iAs and %MMA and were negatively correlated with %DMA, PMI, and SMI before WAs reduction. It can be concluded that higher urinary %iAs and %MMA before WAs reduction increased the probability of skin lesions recovery and improvement, and the risks of skin lesions aggravation and incidence. Higher increase rate of urinary %DMA was positively associated with of skin lesions recovery and improvement. Moreover, higher urinary %iAs and %MMA or lower increase rate of urinary %DMA might increase the risk of skin lesions aggravation.
KeywordUrinary arsenic Skin lesion change Drinking water Metabolism Methylation
DOI10.1007/s11356-018-2512-2
WOS KeywordDRINKING-WATER ; INNER-MONGOLIA ; NORTHERN CHINA ; CAPACITY ; INDIVIDUALS ; BANGLADESH ; CANCER ; AREA ; RISK ; RESIDENTS
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[41601559] ; State Key Program of National Natural Science of China[41230749]
Funding OrganizationNational Natural Science Foundation of China ; State Key Program of National Natural Science of China
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS IDWOS:000441784000082
PublisherSPRINGER HEIDELBERG
Citation statistics
Document Type期刊论文
Identifierhttp://ir.igsnrr.ac.cn/handle/311030/54409
Collection中国科学院地理科学与资源研究所
Corresponding AuthorLi, Hairong; Yang, Linsheng
Affiliation1.Chinese Acad Sci, Key Lab Land Surface Pattern & Simulat, Inst Geog Sci & Nat Resources Res, 11 A Datun Rd, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing, Peoples R China
3.Inner Mongolia Ctr Comprehens Dis Control & Preve, Hohhot, Inner Mongolia, Peoples R China
Recommended Citation
GB/T 7714
Wei, Binggan,Yu, Jiangping,Kong, Chang,et al. Effects of arsenic methylation and metabolism on the changes of arsenic-related skin lesions[J]. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,2018,25(24):24394-24402.
APA Wei, Binggan.,Yu, Jiangping.,Kong, Chang.,Li, Hairong.,Yang, Linsheng.,...&Wu, Kegong.(2018).Effects of arsenic methylation and metabolism on the changes of arsenic-related skin lesions.ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,25(24),24394-24402.
MLA Wei, Binggan,et al."Effects of arsenic methylation and metabolism on the changes of arsenic-related skin lesions".ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH 25.24(2018):24394-24402.
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