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A follow-up study of the development of skin lesions associated with arsenic exposure duration
Wei, Binggan1; Yu, Jiangping1; Kong, Chang1,2; Li, Hairong1,2; Yang, Linsheng1,2; Xia, Yajuan3; Wu, Kegong3
2018-12-01
Source PublicationENVIRONMENTAL GEOCHEMISTRY AND HEALTH
ISSN0269-4042
Volume40Issue:6Pages:2729-2738
Corresponding AuthorLi, Hairong(lihr@igsnrr.ac.cn) ; Yang, Linsheng(yangls@igsnrr.ac.cn)
AbstractLittle information about the development of skin lesions in relation to arsenic exposure duration is available. Therefore, skin lesions in a cohort from the Bameng region of China were diagnosed in 2012 and 2017. The results indicated that the prevalence of hyperkeratosis, pigmentation and depigmentation in 2017 was 64.67, 6.67 and 12.67%. There were 42 and 34% of male subjects and female subjects suffered from skin lesions in 2012. Their morbidity rates were 10.43 and 8.98 per 1000 person-years. In 2017, the values were significantly increased. The prevalence and morbidity rate of skin lesions were positively correlated with age and arsenic levels in drinking water. Males had higher prevalence of skin lesions compared with female. However, the <= 40years female group had higher prevalence of skin lesions. In addition, the increased rate of skin lesions prevalence was negatively correlated with arsenic levels in drinking water. The odds ratios (ORs) showed that the risks of skin lesions were positively associated with the proportion of inorganic arsenic (%iAs) and monomethylarsonic acid (%MMA) in urine, and negatively correlated with arsenic methylation capacity in both 2012 and 2017. It can be concluded that females immigrated from other areas were more susceptible to developing skin lesions. A certain cumulative arsenic exposure dose, which may be existing, significantly increased the prevalence of skin lesions. Longer arsenic exposure duration might elevate the toxicity of iAs to skin lesions and reduce the positive effects of arsenic methylation capacity on skin lesions.
KeywordArsenic Drinking water Skin lesions Development Exposure duration
DOI10.1007/s10653-018-0136-6
WOS KeywordINNER-MONGOLIA ; METHYLATION CAPACITY ; DRINKING-WATER ; WEST-BENGAL ; METABOLITES ; PREVALENCE ; RISK ; POPULATION ; AGE ; CONTAMINATION
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[41601559] ; State Key Program of National Natural Science Foundation of China[41230749]
Funding OrganizationNational Natural Science Foundation of China ; State Key Program of National Natural Science Foundation of China
WOS Research AreaEngineering ; Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Water Resources
WOS SubjectEngineering, Environmental ; Environmental Sciences ; Public, Environmental & Occupational Health ; Water Resources
WOS IDWOS:000452307100030
PublisherSPRINGER
Citation statistics
Document Type期刊论文
Identifierhttp://ir.igsnrr.ac.cn/handle/311030/51449
Collection中国科学院地理科学与资源研究所
Corresponding AuthorLi, Hairong; Yang, Linsheng
Affiliation1.Chinese Acad Sci, Key Lab Land Surface Pattern & Simulat, Inst Geog Sci & Nat Resources Res, 11 A Datun Rd, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing, Peoples R China
3.Inner Mongolia Ctr Comprehens Dis Control & Preve, Hohhot, Inner Mongolia, Peoples R China
Recommended Citation
GB/T 7714
Wei, Binggan,Yu, Jiangping,Kong, Chang,et al. A follow-up study of the development of skin lesions associated with arsenic exposure duration[J]. ENVIRONMENTAL GEOCHEMISTRY AND HEALTH,2018,40(6):2729-2738.
APA Wei, Binggan.,Yu, Jiangping.,Kong, Chang.,Li, Hairong.,Yang, Linsheng.,...&Wu, Kegong.(2018).A follow-up study of the development of skin lesions associated with arsenic exposure duration.ENVIRONMENTAL GEOCHEMISTRY AND HEALTH,40(6),2729-2738.
MLA Wei, Binggan,et al."A follow-up study of the development of skin lesions associated with arsenic exposure duration".ENVIRONMENTAL GEOCHEMISTRY AND HEALTH 40.6(2018):2729-2738.
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