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Dietary flavonoids from Allium mongolicum Regel promotes growth, improves immune, antioxidant status, immune-related signaling molecules and disease resistance in juvenile northern snakehead fish (Channa argus)
Li, Muyang1,2,3; Zhu, Xinming1,2,3; Tian, Jiaxin1,2,3; Liu, Ming4; Wang, Guiqin1,2,3
2019-02-25
Source PublicationAQUACULTURE
ISSN0044-8486
Volume501Pages:473-481
Corresponding AuthorWang, Guiqin(wgqjlau@163.com)
AbstractThe present study was conducted to evaluate the effects of dietary flavonoids from Allium mongolicum Regel (AMRF) supplementation on growth, antioxidant and immune status, immune-related genes expression and disease resistance in Channa argus. A basal diet was supplemented with AMRF at 0, 10, 20 or 40 mg/kg feed for 56 days. The result revealed that weight gain (WG) and specific growth rate (SGR) were significantly increased (P < .05) with the increase of dietary AMRF levels from 0 to 40 mg/kg. All AMRF-supplemented groups (10, 20 or 40 mg/kg) significantly enhanced (P < .05) serum AKP, lysozyme activity, C3, IgM concentration, liver antioxidant enzymes activity (SOD, CAT and GSH-Px) or decreased (P < .05) serum cortisol, liver MDA content, serum ALT and AST activity. Meanwhile, AMRF administration significantly up-regulated (P < .05) the expression of SOD, IgM, HSP70, HSP90, I kappa B-alpha and GR or down-regulated (P < .05) NF-kappa B p65 and inflammatory cytokines (TNF-alpha, IL-1 beta and IL-8) transcription in head kidney of C. argus. After challenge with Aeromonas hydrophila, survival rates in all AMRF treatment groups were significantly increased (P < .05). These results indicated that dietary intake containing AMRF enhanced growth, antioxidant and immune response and regulated immune-related genes expression and increased disease resistance against Aeromonas hydrophila in snakehead fish, with greatest effects in fish given 40 mg/kg AMRF for 56 days.
KeywordAllium mongolicum Regel Growth Immune response Channa argus
DOI10.1016/j.aquaculture.2018.12.011
WOS KeywordMESSENGER-RNA EXPRESSION ; NF-KAPPA-B ; GLUCOCORTICOID-RECEPTOR ; AEROMONAS-HYDROPHILA ; SOYBEAN ISOFLAVONES ; STRESS RESISTANCE ; GENE-EXPRESSION ; CYPRINUS-CARPIO ; COMMON CARP ; GRASS CARP
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31372540] ; Earmarked Fund for Modern Agro-industry Technology Research System[CARS-46]
Funding OrganizationNational Natural Science Foundation of China ; Earmarked Fund for Modern Agro-industry Technology Research System
WOS Research AreaFisheries ; Marine & Freshwater Biology
WOS SubjectFisheries ; Marine & Freshwater Biology
WOS IDWOS:000453540800058
PublisherELSEVIER SCIENCE BV
Citation statistics
Document Type期刊论文
Identifierhttp://ir.igsnrr.ac.cn/handle/311030/51334
Collection中国科学院地理科学与资源研究所
Corresponding AuthorWang, Guiqin
Affiliation1.Jilin Agr Univ, Coll Anim Sci & Technol, Changchun 130118, Jilin, Peoples R China
2.Jilin Agr Univ, Minist Educ, Lab Anim Prod & Qual Secur, Changchun 130118, Jilin, Peoples R China
3.Jilin Agr Univ, Jilin Prov Key Lab Anim Nutr & Feed Sci, Changchun 130118, Jilin, Peoples R China
4.Inst Geog Sci & Nat Resources Res, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Li, Muyang,Zhu, Xinming,Tian, Jiaxin,et al. Dietary flavonoids from Allium mongolicum Regel promotes growth, improves immune, antioxidant status, immune-related signaling molecules and disease resistance in juvenile northern snakehead fish (Channa argus)[J]. AQUACULTURE,2019,501:473-481.
APA Li, Muyang,Zhu, Xinming,Tian, Jiaxin,Liu, Ming,&Wang, Guiqin.(2019).Dietary flavonoids from Allium mongolicum Regel promotes growth, improves immune, antioxidant status, immune-related signaling molecules and disease resistance in juvenile northern snakehead fish (Channa argus).AQUACULTURE,501,473-481.
MLA Li, Muyang,et al."Dietary flavonoids from Allium mongolicum Regel promotes growth, improves immune, antioxidant status, immune-related signaling molecules and disease resistance in juvenile northern snakehead fish (Channa argus)".AQUACULTURE 501(2019):473-481.
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