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Arsenic Metabolites and Methylation Capacity Among Individuals Living in a Rural Area with Endemic Arseniasis in Inner Mongolia, China
Wei B. G.; Yu, J. P.; Li, H. R.; Yang, L. S.; Xia, Y. J.; Wu, K. G.; Gao, J. W.; Guo, Z. W.; Cui, N.
Source PublicationBiological Trace Element Research
2016
Volume170
Issue2
Pages300-308
KeywordArsenic Methylation capacity Arsenic metabolites Drinking water drinking-water genetic polymorphisms skin-lesions urothelial carcinoma southwestern taiwan hyperendemic areas bladder-cancer northern china hetao plain exposure
AbstractMore than 0.3 million individuals are subject to chronic exposure to arsenic via their drinking water in Inner Mongolia, China. To determine arsenic methylation capacity profiles for such individuals, concentrations of urinary arsenic metabolites were measured for 548 subjects using high-performance liquid chromatography and a hydride generator combined with inductively coupled plasma-mass spectrometry. Mean urinary concentrations of dimethylarsonic acid (DMA), monomethylarsonic acid (MMA), inorganic arsenic (iAs), and total arsenic (TAs) were 200.50, 46.71, 52.96, and 300.17 mu g/L, respectively. The %iAs, %DMA, and %MMA were 15.98, 69.72, and 14.29 %. Mean urinary %iAs and %MMA were higher in males, while urinary %DMA was higher in females. There was a strong positive correlation between %iAs and %MMA, with negative correlations between %iAs and %DMA, and %iAs and %MMA. In addition, %iAs and %MMA were positively associated with total arsenic in drinking water (WAs), while %DMA was negatively related with WAs. Regression analysis indicated that the primary methylation index (PMI) and secondary methylation index (SMI) generally decreased with increasing WAs. Females had a higher arsenic methylation capacity compared to males. Younger subjects had lower primary arsenic methylation capacity. However, the secondary arsenic methylation capacity was hardly affected by age. Moreover, both primary and secondary arsenic methylation capacities were negatively related to WAs.
Indexed BySCI
Language英语
ISSN0163-4984
DOI10.1007/s12011-015-0490-5
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document TypeSCI/SSCI论文
Identifierhttp://ir.igsnrr.ac.cn/handle/311030/43302
Collection历年回溯文献
Recommended Citation
GB/T 7714
Wei B. G.,Yu, J. P.,Li, H. R.,et al. Arsenic Metabolites and Methylation Capacity Among Individuals Living in a Rural Area with Endemic Arseniasis in Inner Mongolia, China. 2016.
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