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Properties and inflammatory effects of various size fractions of ambient particulate matter from Beijing on A549 and J774A.1 cells
Wang Bin; Li Kexin; Jin Wenjie; Lu Yan; Zhang Yuzhong; Shen Guofeng; Wang Rong; Shen Huizhong; Li Wei; Huang Ye; Zhang Yanyan; Wang Xilong; Li Xiqing; Liu Wenxin; Cao Hongying; Tao Shu
KeywordParticulate Emissions Cell Culture Macrophages Particle Size Analysis Polycyclic Aromatic Hydrocarbons Zeta Potential
Source PublicationEnvironmental Science and Technology
2013
Volume47Issue:18Pages:10583-10590
AbstractParticulate matter (PM) is a major ambient air pollutant causing millions of premature deaths each year in China. The toxicity of PM is property and size dependent. In this study, ambient PM samples collected in Beijing were divided into five size fractions with nominal aerodynamic ranges of <0.40, 0.40-1.1, 1.1-3.3, 3.3-5.8, and 5.8-10 m. Individual size fractions were characterized for a number of properties including particle size distribution, specific surface area, zeta potential, dithiothreitol (DTT)-based redox ability, and contents of water-soluble organic carbon (WSOC), polycyclic aromatic hydrocarbons (PAHs), selected metals, and endotoxin. Human adenocarcinomic alveolar epithelial cell line A549 and small mouse monocyte-macrophage cell line J774A.1 were tested for their relative viabilities and inflammatory effects (interleukine-8 for A549 and tumor necrosis factor- for J774A.1) after exposure to PM of various sizes. It was found that PM specific area was positively correlated with WSOC, high molecular weight PAHs, DTT-based redox ability, negatively correlated with surface zeta potential and lithophile metals. Several trace metals from combustion sources were enriched in intermediate size fractions. For both endotoxin concentrations of the PM and PM induced inflammatory cytokine expressions by the two cell lines, there were general increasing trends as PM size increased with an exception of the finest fraction, which induced the highest inflammatory effects. It seems that the size dependence of cytokine expression was associated with a number of properties including endotoxin content, zeta potential, settling velocity, metal content, and DTT-based redox ability. 2013 American Chemical Society.
Indexed ByEI
Document TypeEI期刊论文
Identifierhttp://ir.igsnrr.ac.cn/handle/311030/31384
Collection历年回溯文献
Recommended Citation
GB/T 7714
Wang Bin,Li Kexin,Jin Wenjie,et al. Properties and inflammatory effects of various size fractions of ambient particulate matter from Beijing on A549 and J774A.1 cells. 2013.
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