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Associations between blood heavy metal(loid)s and serum heme oxygenase-1 in pregnant women: Do their distribution patterns matter?
Li, Kexin1; Wang, Bin2,3; Yan, Lailai4; Jin, Yu2,3; Li, Zhiyi1; An, Hang2,3; Ren, Mengyuan2,3; Pang, Yiming2,3; Lan, Changxin2,3; Chen, Junxi2,3; Zhang, Yali2,3; Zhang, Le2,3; Ye, Rongwei2,3; Li, Zhiwen2,3; Ren, Aiguo2,3
2021-10-01
Source PublicationENVIRONMENTAL POLLUTION
ISSN0269-7491
Volume286Pages:7
Corresponding AuthorWang, Bin(binwangpku@foxmail.com)
AbstractThe relationship between heavy metal(loid)s exposure and oxidative stress damage is a matter of research interest. Our study aimed to investigate the distribution patterns of the nine heavy metal(loid)s in blood of pregnant women, including four toxic heavy metal(loid)s [arsenic (As), cadmium (Cd), lead (Pb) and mercury (Hg)] and five typical heavy metal(loid)s [manganese (Mn), cobalt (Co), copper (Cu), zinc (Zn), and selenium (Se)] in blood. Blood samples of 348 women were collected and their concentrations in the serum (sr) and blood cells (bc) were measured, as well as serum heme oxygenase-1 (HO-1) (an oxidative stress marker). Total blood (tb) concentrations of these metal(loid)s and serum-to-blood cell concentration ratios (sr/bc) were further calculated. We found Cu mainly accumulated in the serum compared to the blood cells with Cu-sr/bc = 2.30, whereas Co, Se, and As evenly distributed between these two fractions. Other metal(loid)s mainly concentrated in the blood cells. Co-sr, Cu-sr, Cu-bc, Mn-bc, Zn-bc, Cd-bc, Co-tb, Cu-tb, Mn-tb, Zn-tb, Cd-tb, and Cu-sr/bc were negatively associated with serum HO-1, whereas As-sr, As-bc, As-tb, Zn-sr/bc, Cd-sr/bc, and Hg-sr/bc were positively, indicating of their potential toxicity. We concluded that the distribution patterns of blood heavy metal(loid)s, in particular for Cd, Hg and Zn, which either increased in serum or decreased in blood cells, might be associated with elevated serum oxidative stress, should be considered in environmental health assessments.
KeywordHeavy metals Serum Blood cells Oxidative stress Distribution pattern
DOI10.1016/j.envpol.2021.117249
WOS KeywordWHOLE-BLOOD ; OXIDATIVE STRESS ; ANTIOXIDANT ENZYMES ; TRACE-ELEMENTS ; METHYL MERCURY ; METALS ; POPULATION ; SELENIUM ; PLASMA ; CADMIUM
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[41771527] ; National Natural Science Foundation of China[81673177] ; National Natural Science Foundation of China[42077390]
Funding OrganizationNational Natural Science Foundation of China
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS IDWOS:000687470800001
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.igsnrr.ac.cn/handle/311030/165154
Collection中国科学院地理科学与资源研究所
Corresponding AuthorWang, Bin
Affiliation1.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, Beijing 100101, Peoples R China
2.Peking Univ, Key Lab Reprod Hlth, Inst Reprod & Child Hlth, Natl Hlth Commiss Peoples Republ China, Beijing 100191, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
4.Peking Univ, Sch Publ Hlth, Dept Laboratorial Sci & Technol, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Li, Kexin,Wang, Bin,Yan, Lailai,et al. Associations between blood heavy metal(loid)s and serum heme oxygenase-1 in pregnant women: Do their distribution patterns matter?[J]. ENVIRONMENTAL POLLUTION,2021,286:7.
APA Li, Kexin.,Wang, Bin.,Yan, Lailai.,Jin, Yu.,Li, Zhiyi.,...&Ren, Aiguo.(2021).Associations between blood heavy metal(loid)s and serum heme oxygenase-1 in pregnant women: Do their distribution patterns matter?.ENVIRONMENTAL POLLUTION,286,7.
MLA Li, Kexin,et al."Associations between blood heavy metal(loid)s and serum heme oxygenase-1 in pregnant women: Do their distribution patterns matter?".ENVIRONMENTAL POLLUTION 286(2021):7.
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