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Investigation into the content change and distribution of active components in Cordyceps sinensis with growth cycle by direct TOF-SIMS detection
Xia, Meng-Chan1; Zhan, Qin2,4; Cai, Lesi3; Wu, Jiang4; Yang, Lu3; Sun, Suqin3; Liang, Handong4; Li, Zhanping3,5
2021-05-01
Source PublicationMICROCHEMICAL JOURNAL
ISSN0026-265X
Volume164Pages:5
Corresponding AuthorCai, Lesi(cls15@mails.tsinghua.edu.cn) ; Liang, Handong(hdl6688@vip.sina.com) ; Li, Zhanping(zhanpingli@mail.tsinghua.edu.cn)
AbstractAnalyzing the content of active components in Chinese medicines is crucial to evaluate their medicinal value and further promote the development of pharmaceutical technology. In this work, Cordyceps sinensis, a precious Chinese medicine, was characterized by time-of-flight secondary ion mass spectrometry (TOF-SIMS) to measure the content change of amino acids, nucleosides, mannitol and ergosterol with its growth cycle. Direct and sensitive detection of these active components in Cordyceps sinensis was realized by TOF-SIMS without tedious pretreatment process, such as repeated extraction and purification. Due to complex metabolic regulation, amino acids, nucleosides, mannitol and ergosterol showed different changing trends with growth cycle of Cordyceps sinensis. We found that the changing trend of the same active substance in different parts of Cordyceps sinensis varied dramatically. For instance, with the growth cycle of Cordyceps sinensis, the content of mannitol maintained steady growth in the stroma, while fell first and rose later in the worm body. In some growth stage, the content of mannitol in the worm body was about 10 times higher than that in the stroma. We provided a systematically analytical method and rich data base for further research of the extraction of active components and artificial cultivation of Cordyceps sinensis in this study. Meanwhile, TOF-SIMS is verified to be a sensitive, efficient and convenient method to characterize active components in traditional Chinese medicines.
KeywordTOF-SIMS Cordyceps sinensis Active components Content change Growth cycle
DOI10.1016/j.microc.2021.106026
Indexed BySCI
Language英语
Funding ProjectNational Key R&D Program of China[2018YFA0702600]
Funding OrganizationNational Key R&D Program of China
WOS Research AreaChemistry
WOS SubjectChemistry, Analytical
WOS IDWOS:000635089400006
PublisherELSEVIER
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.igsnrr.ac.cn/handle/311030/161837
Collection中国科学院地理科学与资源研究所
Corresponding AuthorCai, Lesi; Liang, Handong; Li, Zhanping
Affiliation1.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, Beijing 100101, Peoples R China
2.Guzhen Cty 1 Middle Sch, Bengbu 233700, Anhui, Peoples R China
3.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China
4.China Univ Min & Technol, Sch Chem & Environm Engn, Beijing 100083, Peoples R China
5.Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Organ Optoelect & Mol Engn, Beijing 100084, Peoples R China
Recommended Citation
GB/T 7714
Xia, Meng-Chan,Zhan, Qin,Cai, Lesi,et al. Investigation into the content change and distribution of active components in Cordyceps sinensis with growth cycle by direct TOF-SIMS detection[J]. MICROCHEMICAL JOURNAL,2021,164:5.
APA Xia, Meng-Chan.,Zhan, Qin.,Cai, Lesi.,Wu, Jiang.,Yang, Lu.,...&Li, Zhanping.(2021).Investigation into the content change and distribution of active components in Cordyceps sinensis with growth cycle by direct TOF-SIMS detection.MICROCHEMICAL JOURNAL,164,5.
MLA Xia, Meng-Chan,et al."Investigation into the content change and distribution of active components in Cordyceps sinensis with growth cycle by direct TOF-SIMS detection".MICROCHEMICAL JOURNAL 164(2021):5.
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