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Source specific PM2.5 associated with heart rate variability in the elderly with coronary heart disease: A community-based panel study
Chen, Xi1; Qiu, Bing2; Zou, Qinpei3; Qiu, Tian1; Li, Runkui4,5; Truong, Ashley6; Qi, Yanmin2; Liu, Tao7; Han, Limin7; Liu, Tiebing2; Chang, Junrui1; Sun, Qi1; Zhu, Ying1; Xu, Dongqun1
2020-12-01
Source PublicationCHEMOSPHERE
ISSN0045-6535
Volume260Pages:13
Corresponding AuthorZhu, Ying(zhuying@nieh.chinacdc.cn) ; Xu, Dongqun(xudq@chinacdc.cn)
AbstractThere is increasingly concern that PM2.5 constituents play a significant role in PM2.5-related cardiovascular outcomes. However, little is known about the associations between specific constituents of PM2.5 and risk for cardiovascular health. To evaluate the exposure to specific chemicals of PM2.5 from various sources and their cardiac effects, a longitudinal investigation was conducted with four repeated measurements of elderly participants' HRV and PM2.5 species in urban Beijing. Multiple chemicals in PM2.5 (metals, ions and PAHs) were characterized for PM2.5 source apportionment and personalized exposure assessment. Five sources were finally identified with specific chemicals as the indicators: oil combustion (1.1%, V & PAHs), secondary particle (11.3%, SO42- & NO3-), vehicle emission (1.2%, Pd), construction dust (28.7%, Mg & Ca), and coal combustion (57.7%, Se & As). As observed, each IQR increase in exposure to oil combustion (V), vehicle emission (Pd), and coal combustion (Se) significantly decreased rMSSD by 13.1% (95% CI: -25.3%, -1.0%), 27.4% (95% CI: -42.9%, -7.6%) and 24.7% (95% CI: -39.2%, -6.9%), respectively, while those of PM2.5 mass with decreases of rMSSD by 11.1% (95% CI: -19.6%, -1.9%) at lag 0. Elevated exposures to specific sources/constituents of PM2.5 disrupt cardiac autonomic function in elderly and have more adverse effects than PM2.5 mass. In the stratified analysis, medication and gender modify the associations of specific chemicals from variable sources with HRV. The findings of this study provide evidence on the roles of influential constituents of ambient air PM2.5 and their sources in terms of their adverse cardiovascular health effects. (C) 2020 Published by Elsevier Ltd.
KeywordPanel study Roles of PM2.5 constituents Source variances Heart rate variability Elderly
DOI10.1016/j.chemosphere.2020.127399
WOS KeywordPOSITIVE MATRIX FACTORIZATION ; AIRBORNE PARTICULATE MATTER ; PLATINUM-GROUP ELEMENTS ; AMBIENT AIR-POLLUTION ; LONG-TERM EXPOSURE ; SOURCE APPORTIONMENT ; CARDIOVASCULAR-DISEASE ; HOSPITAL ADMISSIONS ; MORTALITY ; CONSTITUENTS
Indexed BySCI
Language英语
Funding ProjectPublic Welfare Research Program of the National Health and Family Planning Commission of China[201402022] ; National Natural Science Foundation of China[U1633130] ; National Natural Science Foundation of China[41771435] ; National Natural Science Foundation of China[21677136]
Funding OrganizationPublic Welfare Research Program of the National Health and Family Planning Commission of China ; National Natural Science Foundation of China
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS IDWOS:000575197000002
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.igsnrr.ac.cn/handle/311030/157052
Collection中国科学院地理科学与资源研究所
Corresponding AuthorZhu, Ying; Xu, Dongqun
Affiliation1.Chinese Ctr Dis Control & Prevent, Natl Inst Environm Hlth, 7 Panjiayuan Nanli, Beijing 100021, Peoples R China
2.Civil Aviat Adm China, Civil Aviat Med Ctr, Beijing, Peoples R China
3.Chongqing Ctr Dis Control & Prevent, Chongqing, Peoples R China
4.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, State Key Lab Resources & Environm Informat Syst, Beijing, Peoples R China
6.Brown Univ, Sch Publ Hlth, Providence, RI 02912 USA
7.Civil Aviat Gen Hosp, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Chen, Xi,Qiu, Bing,Zou, Qinpei,et al. Source specific PM2.5 associated with heart rate variability in the elderly with coronary heart disease: A community-based panel study[J]. CHEMOSPHERE,2020,260:13.
APA Chen, Xi.,Qiu, Bing.,Zou, Qinpei.,Qiu, Tian.,Li, Runkui.,...&Xu, Dongqun.(2020).Source specific PM2.5 associated with heart rate variability in the elderly with coronary heart disease: A community-based panel study.CHEMOSPHERE,260,13.
MLA Chen, Xi,et al."Source specific PM2.5 associated with heart rate variability in the elderly with coronary heart disease: A community-based panel study".CHEMOSPHERE 260(2020):13.
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