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Environmental titanium exposure and reproductive health: Risk of low birth weight associated with maternal titanium exposure from a nested case-control study in northern China
Jin, Yu1,2; Li, Zhiyi3; An, Hang1,2; Pang, Yiming1,2; Li, Kexin3; Zhang, Yali1,2; Zhang, Le1,2; Yan, Lailai4; Wang, Bin1,2; Ye, Rongwei1,2; Li, Zhiwen1,2; Ren, Aiguo1,2
2021-01-15
Source PublicationECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
ISSN0147-6513
Volume208Pages:7
Corresponding AuthorYe, Rongwei(yerw@bjmu.edu.cn)
AbstractTitanium (Ti) is commonly used in additives in the form of titanium dioxide (TiO2). However, our understanding of the effect of Ti on reproductive health remains limited. This nested case-control study, performed in a Ti mining exposure field, investigated the association between maternal blood Ti concentration and the risk of low birth weight (LBW), as well as the potential biological mechanism. A total of 45 women who delivered LBW infants (cases) and 352 women with normal birth weight infants (controls) were included. We collected maternal peripheral blood samples in the first or early second trimester to measure Ti concentration in serum (Ti-sr) and blood cells (Ti-bc), as well as inflammatory, lipid, and oxidative stress biomarkers thereof. The demographic characteristics of the women included in the study were also obtained. The results showed that the median total blood Ti concentration (Ti-tb) in the case group was significantly higher than that in the control group (134 vs. 129 ng/mL, P = 0.039). A higher Titb level was associated with a greater risk of LBW [odds ratio = 2.62; 95% confidence interval (CI): 1.16-5.90], but no such association was observed for Ti-sr or Ti-bc after adjusting for potential confounders. The serum lipid biomarkers TC, TG, and total lipids (TL) were all negatively associated with Ti-sr and Ti-tb. Serum 8-OHdG was positively associated with Ti-bc. We concluded that a high Ti-tb during early pregnancy may increase the risk of LBW. Lipid metabolism and oxidative stress may play an important role in the adverse health effects associated with Ti exposure. Thus, our results merit more attention to the probable adverse effects of titanium exposure during pregnancy.
KeywordTitanium Low birth weight Lipids Oxidative stress Pregnancy
DOI10.1016/j.ecoenv.2020.111632
WOS KeywordUMBILICAL-CORD BLOOD ; DIOXIDE NANOPARTICLES ; TISSUE DISTRIBUTION ; OXIDATIVE STRESS ; PREGNANT-WOMEN ; AIR-POLLUTION ; IN-VITRO ; METALS ; PLASMA ; ADULTS
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[41771527] ; National Natural Science Foundation of China[81673177]
Funding OrganizationNational Natural Science Foundation of China
WOS Research AreaEnvironmental Sciences & Ecology ; Toxicology
WOS SubjectEnvironmental Sciences ; Toxicology
WOS IDWOS:000604136800001
PublisherACADEMIC PRESS INC ELSEVIER SCIENCE
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.igsnrr.ac.cn/handle/311030/137871
Collection中国科学院地理科学与资源研究所
Corresponding AuthorYe, Rongwei
Affiliation1.Peking Univ, Inst Reprod & Child Hlth, Key Lab Reprod Hlth, Natl Hlth Commiss Peoples Republ China, Beijing 100191, Peoples R China
2.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
3.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, Beijing 100101, Peoples R China
4.Peking Univ, Sch Publ Hlth, Dept Lab Sci & Technol, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Jin, Yu,Li, Zhiyi,An, Hang,et al. Environmental titanium exposure and reproductive health: Risk of low birth weight associated with maternal titanium exposure from a nested case-control study in northern China[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2021,208:7.
APA Jin, Yu.,Li, Zhiyi.,An, Hang.,Pang, Yiming.,Li, Kexin.,...&Ren, Aiguo.(2021).Environmental titanium exposure and reproductive health: Risk of low birth weight associated with maternal titanium exposure from a nested case-control study in northern China.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,208,7.
MLA Jin, Yu,et al."Environmental titanium exposure and reproductive health: Risk of low birth weight associated with maternal titanium exposure from a nested case-control study in northern China".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 208(2021):7.
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