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The mediated role of complement C3 in PM2.5 exposure and type 2 diabetes mellitus: an elderly panel study in Beijing, China
Tong, Yuanren1,2; Pei, Lu1,2; Luo, Kai1,2; Zhao, Meiduo1,2; Xu, Jing1,2; Li, Ang1,2; Li, Runkui3,4; Yang, Mingan5; Xu, Qun1
2019-11-01
Source PublicationENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
ISSN0944-1344
Volume26Issue:33Pages:34479-34486
Corresponding AuthorXu, Qun(xuqun@ibms.cams.cn)
AbstractDiabetes mellitus (DM) is a common chronic disease worldwide. Ambient air pollution has long been proven to be associated with type 2 diabetes mellitus (T2DM) progression, but the underlying mechanism is not clear yet. In addition, previous studies mainly focused on the prevention of healthy people against the incidence of T2DM. We designed a panel study including two follow-ups and enrolled 39 patients with T2DM living in Beijing. Linear mixed model was fitted to assess the association between two pairs of variables (ambient air pollution exposure and C3 levels, ambient air pollution exposures and T2DM index). Mediation analysis of C3 between ambient air pollution exposure and indicators of T2DM progression was conducted. We found that PM2.5 exposures is are negatively associated with serum complement C3. Given that C3 might act as a protector of pancreas beta cell, PM2.5 exposures could accelerate disease in T2DM populations. No mediation effects were found. This study reveals that exposures to PM2.5 can cause progression of diseases among T2DM populations.
KeywordDiabetes mellitus T2DMpopulation PM2.5 C3 Mediation effects
DOI10.1007/s11356-019-06487-y
WOS KeywordINSULIN-RESISTANCE ; AIR-POLLUTION
Indexed BySCI
Language英语
Funding ProjectChina Medical Board[15-230] ; Gong-Yi Program of Chinese Ministry of Environmental Protection[200909016] ; Chinese Academy of Medical Science Innovation Fund for Medical Sciences[2017-I2M-1-009] ; National Natural Science Foundation of China[41771435] ; China Scholarship Council[201704910297] ; Program of Science and Technology Service Network Initiative (STS) of Chinese Academy of Sciences[Y88Q0300YD]
Funding OrganizationChina Medical Board ; Gong-Yi Program of Chinese Ministry of Environmental Protection ; Chinese Academy of Medical Science Innovation Fund for Medical Sciences ; National Natural Science Foundation of China ; China Scholarship Council ; Program of Science and Technology Service Network Initiative (STS) of Chinese Academy of Sciences
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS IDWOS:000507273700072
PublisherSPRINGER HEIDELBERG
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.igsnrr.ac.cn/handle/311030/131282
Collection中国科学院地理科学与资源研究所
Corresponding AuthorXu, Qun
Affiliation1.Chinese Acad Med Sci, Dept Epidemiol & Biostat, Inst Basic Med Sci, Sch Basic Med,Peking Union Med Coll, Beijing 100005, Peoples R China
2.Chinese Acad Med Sci, Peking Union Med Coll, Ctr Environm & Hlth Sci, Beijing 100005, Peoples R China
3.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, State Key Lab Resources & Environm Informat Syst, Beijing 100101, Peoples R China
5.San Diego State Univ, Grad Sch Publ Hlth, Div Biostat & Epidemiol, San Diego, CA 92182 USA
Recommended Citation
GB/T 7714
Tong, Yuanren,Pei, Lu,Luo, Kai,et al. The mediated role of complement C3 in PM2.5 exposure and type 2 diabetes mellitus: an elderly panel study in Beijing, China[J]. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,2019,26(33):34479-34486.
APA Tong, Yuanren.,Pei, Lu.,Luo, Kai.,Zhao, Meiduo.,Xu, Jing.,...&Xu, Qun.(2019).The mediated role of complement C3 in PM2.5 exposure and type 2 diabetes mellitus: an elderly panel study in Beijing, China.ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,26(33),34479-34486.
MLA Tong, Yuanren,et al."The mediated role of complement C3 in PM2.5 exposure and type 2 diabetes mellitus: an elderly panel study in Beijing, China".ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH 26.33(2019):34479-34486.
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